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Pyk2 regulates H(+)-ATPase-mediated proton secretion in the outer medullary collecting duct via an ERK1/2 signaling pathway
Acid-secreting intercalated cells respond to changes in systemic pH through regulation of apical H(+) transporters. Little is known about the mechanism by which these cells sense changes in extracellular pH (pH(o)). Pyk2 is a nonreceptor tyrosine kinase activated by autophosphorylation at Tyr402 by...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518186/ https://ncbi.nlm.nih.gov/pubmed/22811489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00008.2012 |
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