PERTURBATION OF SODIUM CHANNEL STRUCTURE BY AN INHERITED LONG QT SYNDROME MUTATION

The cardiac voltage-gated sodium channel (Na(V)1.5) underlies impulse conduction in the heart and its depolarization-induced inactivation is essential in control of the duration of the QT interval of the electrocardiogram (ECG). Perturbation of Nav1.5 inactivation by drugs or inherited mutation can...

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Autores principales: Glaaser, Ian W., Osteen, Jeremiah D., Puckerin, Akil, Sampson, Kevin J., Jin, Xiangshu, Kass, Robert S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518026/
https://ncbi.nlm.nih.gov/pubmed/22426227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1717
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