α-1-Syntrophin Mutation and the Long-QT Syndrome: A Disease of Sodium Channel Disruption

BACKGROUND: Long-QT syndrome (LQTS) is an inherited disorder associated with sudden cardiac death. The cytoskeletal protein syntrophin-α(1) (SNTA1) is known to interact with the cardiac sodium channel (hNa(v)1.5), and we hypothesized that SNTA1 mutations might cause phenotypic LQTS in patients with...

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Autori principali: Wu, Geru, Ai, Tomohiko, Kim, Jeffrey J., Mohapatra, Bhagyalaxmi, Xi, Yutao, Li, Zhaohui, Abbasi, Shahrzad, Purevjav, Enkhsaikhan, Samani, Kaveh, Ackerman, Michael J, Qi, Ming, Moss, Arthur J., Shimizu, Wataru, Towbin, Jeffrey A., Cheng, Jie, Vatta, Matteo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726717/
https://ncbi.nlm.nih.gov/pubmed/19684871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.108.769224
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