α-1-Syntrophin Mutation and the Long-QT Syndrome: A Disease of Sodium Channel Disruption

BACKGROUND: Long-QT syndrome (LQTS) is an inherited disorder associated with sudden cardiac death. The cytoskeletal protein syntrophin-α(1) (SNTA1) is known to interact with the cardiac sodium channel (hNa(v)1.5), and we hypothesized that SNTA1 mutations might cause phenotypic LQTS in patients with...

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Huvudupphovsmän: Wu, Geru, Ai, Tomohiko, Kim, Jeffrey J., Mohapatra, Bhagyalaxmi, Xi, Yutao, Li, Zhaohui, Abbasi, Shahrzad, Purevjav, Enkhsaikhan, Samani, Kaveh, Ackerman, Michael J, Qi, Ming, Moss, Arthur J., Shimizu, Wataru, Towbin, Jeffrey A., Cheng, Jie, Vatta, Matteo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726717/
https://ncbi.nlm.nih.gov/pubmed/19684871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.108.769224
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