Coordination of DNA repair by NEIL1 and PARP-1: a possible link to aging

Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammal...

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Detalhes bibliográficos
Main Authors: Noren Hooten, Nicole, Fitzpatrick, Megan, Kompaniez, Kari, Jacob, Kimberly D., Moore, Brittany R., Nagle, Julia, Barnes, Janice, Lohani, Althaf, Evans, Michele K.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517938/
https://ncbi.nlm.nih.gov/pubmed/23104860
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