Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses

BACKGROUND: A Phase I dose escalation first in man study assessed maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and recommended Phase II dose of TP300, a water soluble prodrug of the Topo-1 inhibitor TP3076, and active metabolite, TP3011. METHODS: Eligible patients with refractory advan...

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Autori principali: Anthoney, D Alan, Naik, Jay, MacPherson, Iain RJ, Crawford, Donna, Hartley, John M, Hartley, Janet A, Saito, Tomohisa, Abe, Masaichi, Jones, Keith, Miwa, Masanori, Twelves, Christopher, Evans, TRJ
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517777/
https://ncbi.nlm.nih.gov/pubmed/23170896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-536
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