Novel anti-HER2 monoclonal antibodies: synergy and antagonism with tumor necrosis factor-α

BACKGROUND: One-third of breast cancers display amplifications of the ERBB2 gene encoding the HER2 kinase receptor. Trastuzumab, a humanized antibody directed against an epitope on subdomain IV of the extracellular domain of HER2 is used for therapy of HER2-overexpressing mammary tumors. However, ma...

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Autors principals: Ceran, Ceyhan, Cokol, Murat, Cingoz, Sultan, Tasan, Ipek, Ozturk, Mehmet, Yagci, Tamer
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517359/
https://ncbi.nlm.nih.gov/pubmed/23033967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-450
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