Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression

Mutations in genes involved in DNA replication such as FEN1, can cause single-stranded DNA breaks (SSBs) and subsequent collapse of DNA replication forks leading to DNA replication stresses. Persistent replication stresses normally induce p53-mediated senescence or apoptosis to prevent tumor progres...

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Hauptverfasser: Zheng, Li, Dai, Huifang, Zhou, Mian, Li, Xiaojin, Liu, Changwei, Guo, Zhigang, Wu, Xiwei, Wu, Jun, Wang, Charles, Zhong, John, Huang, Qin, Garcia-Aguilar, Julio, Pfeifer, Gerd P., Shen, Binghui
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517178/
https://ncbi.nlm.nih.gov/pubmed/22569363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1825
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