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Combined Ligand- and Structure-based Virtual Screening Protocol Identifies Novel Submicromolar PPARγ Partial Agonists Title

PPARγ is involved in expression of genes that control glucose and lipid metabolism. PPARγ is the molecular target of the thiazolidinedione (TZD) class of antidiabetic drugs. However, despite their clinical use these drugs are related to numerous adverse effects, which are related to their full activ...

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Detalhes bibliográficos
Main Authors: Vidović, Dušica, Busby, Scott A., Griffin, Patrick R., Schürer, Stephan C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517154/
https://ncbi.nlm.nih.gov/pubmed/21162086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000428
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