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Functional significance of tapasin membrane association and disulfide linkage to ERp57 in MHC class I presentation
Tapasin is disulfide linked to ERp57 within the peptide loading complex. In cell-free assays, a soluble variant of the tapasin-ERp57 dimer recruits MHC class I molecules and promotes peptide binding to them while soluble tapasin alone does not. Here we show that within cells, tapasin conjugation wit...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3517023/ https://ncbi.nlm.nih.gov/pubmed/19701894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939536 |
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