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Functional significance of tapasin membrane association and disulfide linkage to ERp57 in MHC class I presentation

Tapasin is disulfide linked to ERp57 within the peptide loading complex. In cell-free assays, a soluble variant of the tapasin-ERp57 dimer recruits MHC class I molecules and promotes peptide binding to them while soluble tapasin alone does not. Here we show that within cells, tapasin conjugation wit...

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Bibliografiska uppgifter
Huvudupphovsmän: Vigneron, Nathalie, Peaper, David R., Leonhardt, Ralf M., Cresswell, Peter
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517023/
https://ncbi.nlm.nih.gov/pubmed/19701894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939536
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