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Jostling for Position: Optimizing Linker Location in the Design of Estrogen Receptor-targeting PROTACs
Estrogen receptor-alpha (ER) antagonists have been widely used for breast cancer therapy. Despite initial responsiveness, eventually hormone-sensitive ER-positive cancer cells develop resistance to ER antagonists. It has been shown that, in most of these resistant tumor cells, the ER is expressed an...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516907/ https://ncbi.nlm.nih.gov/pubmed/20512796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000146 |
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