Chargement en cours...
Synthesis of new (-)-Bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase
The malarial PfA-M1 metallo-aminopeptidase is considered a putative drug target. The natural product dipeptide mimetic, bestatin, is a potent inhibitor of PfA-M1. Herein we present a new, efficient and high-yielding protocol for the synthesis of bestatin derivatives from natural and unnatural N-Boc-...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516848/ https://ncbi.nlm.nih.gov/pubmed/21366301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101227t |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|