Enforced Expression of Roquin Protein in T Cells Exacerbates the Incidence and Severity of Experimental Arthritis

To investigate the role of Roquin, a RING-type ubiquitin ligase family member, we used transgenic mice with enforced Roquin expression in T cells, with collagen-induced arthritis (CIA). Wild-type (WT) and Roquin transgenic (Tg) mice were immunized with bovine type II collagen (CII). Arthritis severi...

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Hauptverfasser: Ji, Young Rae, Kim, Hei Jung, Yu, Dong Hoon, Bae, Ki Beom, Park, Seo Jin, Yi, Jun Koo, Kim, Nari, Park, Si Jun, Oh, Keon Bong, Hwang, Sung Soo, Lee, Sanggyu, Kim, Sung-Hyun, Kim, Myoung Ok, Lee, Jeong Woong, Ryoo, Zae Young
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516770/
https://ncbi.nlm.nih.gov/pubmed/23066015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374835
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