Enforced Expression of Roquin Protein in T Cells Exacerbates the Incidence and Severity of Experimental Arthritis

To investigate the role of Roquin, a RING-type ubiquitin ligase family member, we used transgenic mice with enforced Roquin expression in T cells, with collagen-induced arthritis (CIA). Wild-type (WT) and Roquin transgenic (Tg) mice were immunized with bovine type II collagen (CII). Arthritis severi...

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Detalhes bibliográficos
Main Authors: Ji, Young Rae, Kim, Hei Jung, Yu, Dong Hoon, Bae, Ki Beom, Park, Seo Jin, Yi, Jun Koo, Kim, Nari, Park, Si Jun, Oh, Keon Bong, Hwang, Sung Soo, Lee, Sanggyu, Kim, Sung-Hyun, Kim, Myoung Ok, Lee, Jeong Woong, Ryoo, Zae Young
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516770/
https://ncbi.nlm.nih.gov/pubmed/23066015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374835
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