Enforced Expression of Roquin Protein in T Cells Exacerbates the Incidence and Severity of Experimental Arthritis

To investigate the role of Roquin, a RING-type ubiquitin ligase family member, we used transgenic mice with enforced Roquin expression in T cells, with collagen-induced arthritis (CIA). Wild-type (WT) and Roquin transgenic (Tg) mice were immunized with bovine type II collagen (CII). Arthritis severi...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ji, Young Rae, Kim, Hei Jung, Yu, Dong Hoon, Bae, Ki Beom, Park, Seo Jin, Yi, Jun Koo, Kim, Nari, Park, Si Jun, Oh, Keon Bong, Hwang, Sung Soo, Lee, Sanggyu, Kim, Sung-Hyun, Kim, Myoung Ok, Lee, Jeong Woong, Ryoo, Zae Young
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2012
Θέματα:
Immunology
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516770/
https://ncbi.nlm.nih.gov/pubmed/23066015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374835
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