Self-cleavage of Human CLCA1 Protein by a Novel Internal Metalloprotease Domain Controls Calcium-activated Chloride Channel Activation

The chloride channel calcium-activated (CLCA) family are secreted proteins that regulate both chloride transport and mucin expression, thus controlling the production of mucus in respiratory and other systems. Accordingly, human CLCA1 is a critical mediator of hypersecretory lung diseases, such as a...

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Bibliografiska uppgifter
Huvudupphovsmän: Yurtsever, Zeynep, Sala-Rabanal, Monica, Randolph, David T., Scheaffer, Suzanne M., Roswit, William T., Alevy, Yael G., Patel, Anand C., Heier, Richard F., Romero, Arthur G., Nichols, Colin G., Holtzman, Michael J., Brett, Tom J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516759/
https://ncbi.nlm.nih.gov/pubmed/23112050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410282
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