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Reengineering the Collision Coupling and Diffusion Mode of the A(2A)-adenosine Receptor: PALMITOYLATION IN HELIX 8 RELIEVES CONFINEMENT
The A(2A)-adenosine receptor undergoes restricted collision coupling with its cognate G protein G(s) and lacks a palmitoylation site at the end of helix 8 in its intracellular C terminus. We explored the hypothesis that there was a causal link between the absence of a palmitoyl moiety and restricted...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516756/ https://ncbi.nlm.nih.gov/pubmed/23071116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.393579 |
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