KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer

BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma viral oncogenes homologue (KRAS) mutations have been reported to have an im...

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Hlavní autoři: Birkeland, E, Wik, E, Mjøs, S, Hoivik, E A, Trovik, J, Werner, H M J, Kusonmano, K, Petersen, K, Raeder, M B, Holst, F, Øyan, A M, Kalland, K-H, Akslen, L A, Simon, R, Krakstad, C, Salvesen, H B
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Genetics & Genomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516681/
https://ncbi.nlm.nih.gov/pubmed/23099803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.477
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