PARAOXONASE 1 (PON1) AS A GENETIC DETERMINANT OF SUSCEPTIBILITY TO ORGANOPHOSPHATE TOXICITY

Paraoxonase (PON1) is an A-esterase capable of hydrolyzing the active metabolites (oxons) of a number of organophosphorus (OP) insecticides such as parathion, diazinon and chlorpyrifos. PON1 activity is highest in liver and in plasma. Human PON1 displays two polymorphisms in the coding region (Q192R...

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Detaylı Bibliyografya
Asıl Yazarlar: Costa, Lucio G., Giordano, Gennaro, Cole, Toby B., Marsillach, Judit, Furlong, Clement E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516631/
https://ncbi.nlm.nih.gov/pubmed/22884923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2012.07.011
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