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Genomic Hallmarks of Genes Involved in Chromosomal Translocations in Hematological Cancer

Reciprocal chromosomal translocations (RCTs) leading to the formation of fusion genes are important drivers of hematological cancers. Although the general requirements for breakage and fusion are fairly well understood, quantitative support for a general mechanism of RCT formation is still lacking....

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Detalhes bibliográficos
Main Authors: Shugay, Mikhail, Ortiz de Mendíbil, Iñigo, Vizmanos, José L., Novo, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516532/
https://ncbi.nlm.nih.gov/pubmed/23236267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002797
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