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Genomic Hallmarks of Genes Involved in Chromosomal Translocations in Hematological Cancer

Reciprocal chromosomal translocations (RCTs) leading to the formation of fusion genes are important drivers of hematological cancers. Although the general requirements for breakage and fusion are fairly well understood, quantitative support for a general mechanism of RCT formation is still lacking....

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Autors principals: Shugay, Mikhail, Ortiz de Mendíbil, Iñigo, Vizmanos, José L., Novo, Francisco J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516532/
https://ncbi.nlm.nih.gov/pubmed/23236267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002797
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