Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures

Core functions of autophagy are mediated by ubiquitin-like protein (UBL) cascades, in which a homodimeric E1 enzyme, Atg7, directs the UBLs Atg8 and Atg12 to their respective E2 enzymes, Atg3 and Atg10. Crystallographic and mutational analyses of yeast (Atg7 – Atg3)(2) and (Atg7 –Atg10)(2) complexes...

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Main Authors: Kaiser, Stephen E., Mao, Kai, Taherbhoy, Asad M., Yu, Shanshan, Olszewski, Jennifer L., Duda, David M., Kurinov, Igor, Deng, Alan, Fenn, Timothy D., Klionsky, Daniel J., Schulman, Brenda A.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515690/
https://ncbi.nlm.nih.gov/pubmed/23142976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2415
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