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Mapping the Catechol Binding Site in Dopamine D(1) Receptors: Synthesis and Evaluation of Two Parallel Series of Bicyclic Dopamine Analogues
A novel class of isochroman dopamine analogues, 1, originally reported by Abbott Laboratories, had greater than 100-fold selectivity for D1-like vs. D2-like receptors. We synthesized a parallel series of chroman compounds, 2, and showed that repositioning the oxygen in the heterocyclic ring reduced...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3515654/ https://ncbi.nlm.nih.gov/pubmed/21538900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100010 |
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