Elastase and Tryptase Govern TNFα-Mediated Production of Active Chemerin by Adipocytes

Chemerin is a leukocyte chemoattractant and adipokine with important immune and metabolic roles. Chemerin, secreted in an inactive form prochemerin, undergoes C-terminal proteolytic cleavage to generate active chemerin, a ligand for the chemokine-like receptor-1 (CMKLR1). We previously identified th...

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Autores principales: Parlee, Sebastian D., McNeil, Jenna O., Muruganandan, Shanmugam, Sinal, Christopher J., Goralski, Kerry B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515524/
https://ncbi.nlm.nih.gov/pubmed/23227233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051072
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