Defining the Antigenic Diversity of Plasmodium falciparum Apical Membrane Antigen 1 and the Requirements for a Multi-Allele Vaccine against Malaria

Apical Membrane Antigen 1 (AMA1) is a leading malaria vaccine candidate and a target of naturally-acquired human immunity. Plasmodium falciparum AMA1 is polymorphic and in vaccine trials it induces strain-specific protection. This antigenic diversity is a major roadblock to development of AMA1 as a...

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Main Authors: Drew, Damien R., Hodder, Anthony N., Wilson, Danny W., Foley, Michael, Mueller, Ivo, Siba, Peter M., Dent, Arlene E., Cowman, Alan F., Beeson, James G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515520/
https://ncbi.nlm.nih.gov/pubmed/23227229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051023
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