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Room-temperature X-ray diffraction studies of cisplatin and carboplatin binding to His15 of HEWL after prolonged chemical exposure
The anticancer complexes cisplatin and carboplatin are known to bind to both the N(δ) and the N(∊) atoms of His15 of hen egg-white lysozyme (HEWL) in the presence of dimethyl sulfoxide (DMSO). However, neither binds in aqueous media after 4 d of crystallization and crystal growth, suggesting that DM...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3515368/ https://ncbi.nlm.nih.gov/pubmed/23143236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112042005 |
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