Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis

BACKGROUND: Transforming growth factor beta (TGFβ) is upregulated in chronic inflammation, where it plays a key role in wound healing and promoting fibrosis. However, little is known about the peripheral effects of TGFβ on nociception. METHODS: We tested the in vitro effects of TGFβ1 on the excitabi...

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Detalhes bibliográficos
Main Authors: Zhu, Yaohui, Colak, Tugba, Shenoy, Mohan, Liu, Liansheng, Mehta, Kshama, Pai, Reetesh, Zou, Bende, Xie, Xinmin Simon, Pasricha, Pankaj J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515355/
https://ncbi.nlm.nih.gov/pubmed/22963239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-65
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