A novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1α axis and disrupting cell polarity and migration

Endothelial tubular morphogenesis relies on an exquisite interplay of microtubule dynamics and actin remodeling to propel directed cell migration. Recently, the dynamicity and integrity of microtubules have been implicated in the trafficking and efficient translation of the mRNA for HIF-1α (hypoxia-...

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Autori principali: Karna, Prasanthi, Rida, Padmashree C.G., Turaga, Ravi Chakra, Gao, Jinmin, Gupta, Meenakshi, Fritz, Andreas, Werner, Erica, Yates, Clayton, Zhou, Jun, Aneja, Ritu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514903/
https://ncbi.nlm.nih.gov/pubmed/22678119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs200
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