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Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters

Pancreatic ductal adenocarcinoma (PDAC) has a mortality rate near 100%. Smoking is a documented risk factor. However, the mechanisms of smoking-associated pancreatic carcinogenesis are poorly understood. We have shown that binding of nicotine to nicotinic acetylcholine receptors (nAChRs) expressing...

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Autori principali: Al-Wadei, Mohammed H., Al-Wadei, Hussein A.N., Schuller, Hildegard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514900/
https://ncbi.nlm.nih.gov/pubmed/22791813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs229
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