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Inhibitors of cathepsins B and L induce autophagy and cell death in neuroblastoma cells

This study was designed to test the hypothesis that specific inhibition of cathepsins B and L will cause death of neuroblastoma cells. Five compounds that differ in mode and rate of inhibition of these two enzymes were all shown to cause neuroblastoma cell death. Efficacy of the different compounds...

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Detalhes bibliográficos
Main Authors: Cartledge, Donna M., Colella, Rita, Glazewski, Lisa, Lu, Guizhen, Mason, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514655/
https://ncbi.nlm.nih.gov/pubmed/22549440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9826-6
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