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RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation
Expression of the intrinsic cellular caspase inhibitor XIAP is regulated primarily at the level of protein synthesis. The 5′ untranslated region harbours an Internal Ribosome Entry Site (IRES) motif that supports cap-independent translation of XIAP mRNA during conditions of cellular stress. In this...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3514411/ https://ncbi.nlm.nih.gov/pubmed/21102524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.527 |
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