Drug-binding energetics of human α-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations

This study utilizes sensitive, modern isothermal titration calorimetric (ITC) methods to characterize the microscopic thermodynamic parameters that drive the binding of basic drugs to α-1-acid glycoprotein (AGP) and thereby rationalize the thermodynamic data in relation to docking models and crystal...

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Detalhes bibliográficos
Main Authors: Huang, Johnny X., Cooper, Matthew A., Baker, Mark A., Azad, Mohammad A.K., Nation, Roger L., Li, Jian, Velkov, Tony
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513776/
https://ncbi.nlm.nih.gov/pubmed/23192962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.2221
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