Drug-binding energetics of human α-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations

This study utilizes sensitive, modern isothermal titration calorimetric (ITC) methods to characterize the microscopic thermodynamic parameters that drive the binding of basic drugs to α-1-acid glycoprotein (AGP) and thereby rationalize the thermodynamic data in relation to docking models and crystal...

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Bibliographic Details
Main Authors: Huang, Johnny X., Cooper, Matthew A., Baker, Mark A., Azad, Mohammad A.K., Nation, Roger L., Li, Jian, Velkov, Tony
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513776/
https://ncbi.nlm.nih.gov/pubmed/23192962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.2221
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