Development and evaluation of a thermosensitive vaginal gel containing raltegravir + efavirenz loaded nanoparticles for HIV prophylaxis

The objective of this investigation was to develop a thermosensitive vaginal gel containing raltegravir + efavirenz loaded PLGA nanoparticles (RAL-EFV-NPs) for pre-exposure prophylaxis of HIV. RAL-EFV-NPs were fabricated using a modified emulsion-solvent evaporation method and characterized for size...

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Detalhes bibliográficos
Main Authors: Date, Abhijit A., Shibata, Annemarie, Goede, Michael, Sanford, Bridget, La Bruzzo, Krista, Belshan, Michel, Destache, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513487/
https://ncbi.nlm.nih.gov/pubmed/23041201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2012.09.015
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