Antiretroviral release from poly(dl-lactide-co-glycolide) nanoparticles in mice

OBJECTIVES: Free ritonavir, lopinavir and efavirenz injected intraperitoneally were compared with antiretroviral (AR) nanoparticles (NPs). METHODS: This is a prospective study in BALB/c mice comparing the pharmacokinetics of free drugs with AR NPs. All animals received free drugs or AR NPs (20 mg/kg...

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Bibliographic Details
Main Authors: Destache, Christopher J., Belgum, Todd, Goede, Michael, Shibata, Annemarie, Belshan, Michael A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941676/
https://ncbi.nlm.nih.gov/pubmed/20729545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkq318
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