Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs present...

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Detalhes bibliográficos
Main Authors: Hunger, Robert E., Sieling, Peter A., Ochoa, Maria Teresa, Sugaya, Makoto, Burdick, Anne E., Rea, Thomas H., Brennan, Patrick J., Belisle, John T., Blauvelt, Andrew, Porcelli, Steven A., Modlin, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC351318/
https://ncbi.nlm.nih.gov/pubmed/14991068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419655
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