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TGF-β1 induces bone marrow reticulin fibrosis in hairy cell leukemia

The mechanisms that lead to reticulin fibrosis of bone marrow (BM) in hairy cell leukemia (HCL) are not fully understood. We therefore investigated the involvement of TGF-β1, a potent fibrogenic cytokine, in this process. Immunoassays revealed that TGF-β1 is present at higher concentrations in BM, s...

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Main Authors: Shehata, Medhat, Schwarzmeier, Josef D., Hilgarth, Martin, Hubmann, Rainer, Duechler, Markus, Gisslinger, Heinz
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2004
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC351317/
https://ncbi.nlm.nih.gov/pubmed/14991065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419540
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