115 Caspase-4 Plays a Role in the Activation of the Cryopyrin/NLRP3 Inflammasome

BACKGROUND: The inflammasome is a multi-protein complex which regulates the activation of caspase-1. This activation results in the cleavage and secretion of the IL-1β super family cytokines, IL-1β, IL-18, and IL-33. NLR family-pyrin domain containing- 3 (NLRP3) is a nucleotide binding domain-leucin...

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Main Authors: Cox, Ruan, Aljubran, Salman, Lockey, Richard F., Kolliputi, Narasaiah
Format: Artigo
Jezik:Inglês
Izdano: World Allergy Organization Journal 2012
Teme:
Abstracts of the XXII World Allergy Congress
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512947/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.WOX.0000411860.83535.b0
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