Dependency of colorectal cancer on a TGF-beta-driven programme in stromal cells for metastasis initiation

A large proportion of colorectal cancers (CRCs) display mutational inactivation of the TGF-beta pathway yet paradoxically, they are characterized by elevated TGF-beta production. Here, we unveil a prometastatic programme induced by TGF-beta in the microenvironment that associates with a high-risk of...

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Detalhes bibliográficos
Main Authors: Calon, Alexandre, Espinet, Elisa, Palomo-Ponce, Sergio, Tauriello, Daniele V. F., Iglesias, Mar, Céspedes, María Virtudes, Sevillano, Marta, Nadal, Cristina, Jung, Peter, Zhang, Xiang H.-F., Byrom, Daniel, Riera, Antoni, Rossell, David, Mangues, Ramón, Massague, Joan, Sancho, Elena, Batlle, Eduard
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512565/
https://ncbi.nlm.nih.gov/pubmed/23153532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.08.013
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