Pharmacokinetics and Biodistribution Study of 7A7 Anti-Mouse Epidermal Growth Factor Receptor Monoclonal Antibody and Its F(ab')(2) Fragment in an Immunocompetent Mouse Model

Immunocompetent mice, Fc receptor γ-chain deficient mice (Fcer1g(−/−)), and molecular tools as F(ab′)(2) bivalent fragments appear as the most suitable biological models to study the mechanisms of the action of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs). In vivo experi...

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Detalhes bibliográficos
Main Authors: Rabasa Capote, Ailem, González, Jorge Ernesto, Rodríguez-Vera, Leyanis, López, Armando, Sánchez Ramírez, Belinda, Garrido Hidalgo, Greta
Formato: Artigo
Idioma:Inglês
Publicado em: International Scholarly Research Network 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512310/
https://ncbi.nlm.nih.gov/pubmed/23227357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5402/2012/417515
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