Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates

Tuberculosis (TB) remains a global health burden for which safe vaccines are needed. BCG has limitations as a TB vaccine so we have focused on live attenuated Mycobacterium tuberculosis mutants as vaccine candidates. Prior to human studies, however, it is necessary to demonstrate safety in non-human...

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Detalhes bibliográficos
Main Authors: Larsen, Michelle H., Biermann, Karolin, Chen, Bing, Hsu, Tsungda, Sambandamurthy, Vasan K., Lackner, Andrew A., Aye, Pyone Pyone, Didier, Peter, Huang, Dan, Shao, Linyun, Wei, Huiyong, Letvin, Norman L., Frothingham, Richard, Haynes, Barton F., Chen, Zheng W., Jacobs, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512200/
https://ncbi.nlm.nih.gov/pubmed/19500524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.05.050
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