Role of TSH in the Spontaneous Development of Asymmetrical Thyroid Carcinoma in Mice with a Targeted Mutation in a Single Allele of the Thyroid Hormone-β Receptor

Mutations of the thyroid hormone receptor-β gene (THRB) cause resistance to thyroid hormone (RTH). A mouse model of RTH harboring a homozygous thyroid hormone receptor (TR)-β mutation known as PV (Thrb(PV/PV) mouse) spontaneously develops follicular thyroid cancer (FTC). Similar to RTH patients with...

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Main Authors: Zhao, Li, Zhu, Xuguang, Won Park, Jeong, Fozzatti, Laura, Willingham, Mark, Cheng, Sheue-yann
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2012
Assuntos:
Thyroid-TRH-TSH
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512015/
https://ncbi.nlm.nih.gov/pubmed/22919057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1600
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