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Host epithelial geometry regulates breast cancer cell invasiveness

Breast tumor development is regulated in part by cues from the local microenvironment, including interactions with neighboring nontumor cells as well as the ECM. Studies using homogeneous populations of breast cancer cell lines cultured in 3D ECM have shown that increased ECM stiffness stimulates tu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Boghaert, Eline, Gleghorn, Jason P., Lee, KangAe, Gjorevski, Nikolce, Radisky, Derek C., Nelson, Celeste M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511712/
https://ncbi.nlm.nih.gov/pubmed/23150585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118872109
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