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Host epithelial geometry regulates breast cancer cell invasiveness

Breast tumor development is regulated in part by cues from the local microenvironment, including interactions with neighboring nontumor cells as well as the ECM. Studies using homogeneous populations of breast cancer cell lines cultured in 3D ECM have shown that increased ECM stiffness stimulates tu...

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Autores principales: Boghaert, Eline, Gleghorn, Jason P., Lee, KangAe, Gjorevski, Nikolce, Radisky, Derek C., Nelson, Celeste M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511712/
https://ncbi.nlm.nih.gov/pubmed/23150585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118872109
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