Assessment of Genotype Imputation Performance Using 1000 Genomes in African American Studies

Genotype imputation, used in genome-wide association studies to expand coverage of single nucleotide polymorphisms (SNPs), has performed poorly in African Americans compared to less admixed populations. Overall, imputation has typically relied on HapMap reference haplotype panels from Africans (YRI)...

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Detalhes bibliográficos
Main Authors: Hancock, Dana B., Levy, Joshua L., Gaddis, Nathan C., Bierut, Laura J., Saccone, Nancy L., Page, Grier P., Johnson, Eric O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511547/
https://ncbi.nlm.nih.gov/pubmed/23226329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050610
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