Silodosin Inhibits Noradrenaline-Activated Transcription Factors Elk1 and SRF in Human Prostate Smooth Muscle

BACKGROUND: The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin. Activation of Elk1 and SRF results in bin...

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Autores principales: Hennenberg, Martin, Strittmatter, Frank, Beckmann, Christer, Rutz, Beata, Füllhase, Claudius, Waidelich, Raphaela, Montorsi, Francesco, Hedlund, Petter, Andersson, Karl-Erik, Stief, Christian G., Gratzke, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511420/
https://ncbi.nlm.nih.gov/pubmed/23226423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050904
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