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P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate

Prostate smooth muscle tone and hyperplastic growth are involved in the pathophysiology and treatment of male lower urinary tract symptoms (LUTS). Available drugs are characterized by limited efficacy. Patients’ adherence is particularly low to combination therapies of 5α-reductase inhibitors and α(...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Wang, Yiming, Gratzke, Christian, Tamalunas, Alexander, Wiemer, Nicolas, Ciotkowska, Anna, Rutz, Beata, Waidelich, Raphaela, Strittmatter, Frank, Liu, Chunxiao, Stief, Christian G., Hennenberg, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829229/
https://ncbi.nlm.nih.gov/pubmed/27071060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153312
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