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Identification and Characterisation of the RalA-ERp57 Interaction: Evidence for GDI Activity of ERp57

RalA is a membrane-associated small GTPase that regulates vesicle trafficking. Here we identify a specific interaction between RalA and ERp57, an oxidoreductase and signalling protein. ERp57 bound specifically to the GDP-bound form of RalA, but not the GTP-bound form, and inhibited the dissociation...

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Detalhes bibliográficos
Main Authors: Brymora, Adam, Duggin, Iain G., Berven, Leise A., van Dam, Ellen M., Roufogalis, Basil D., Robinson, Phillip J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511393/
https://ncbi.nlm.nih.gov/pubmed/23226417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050879
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