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The Scribble Polarity Protein Stabilizes E-Cadherin/p120-Catenin Binding and Blocks Retrieval of E-Cadherin to the Golgi

Several polarity proteins, including Scribble (Scrb) have been implicated in control of vesicle traffic, and in particular the endocytosis of E-cadherin, but through unknown mechanisms. We now show that depletion of Scrb enhances endocytosis of E-cadherin by weakening the E-cadherin-p120catenin inte...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lohia, Madhura, Qin, Yi, Macara, Ian G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511384/
https://ncbi.nlm.nih.gov/pubmed/23226478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051130
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