Tumor Phosphatidylinositol-3-Kinase Signaling and Development of Metastatic Disease in Locally Advanced Rectal Cancer

BACKGROUND: Recognizing EGFR as key orchestrator of the metastatic process in colorectal cancer, but also the substantial heterogeneity of responses to anti-EGFR therapy, we examined the pattern of composite tumor kinase activities governed by EGFR-mediated signaling that might be implicated in deve...

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Hauptverfasser: Ree, Anne Hansen, Kristensen, Annette Torgunrud, Saelen, Marie Grøn, de Wijn, Rik, Edvardsen, Hege, Jovanovic, Jovana, Abrahamsen, Torveig Weum, Dueland, Svein, Flatmark, Kjersti
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511283/
https://ncbi.nlm.nih.gov/pubmed/23226389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050806
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