Low molecular weight chitosan conjugated with folate for siRNA delivery in vitro: optimization studies

The low transfection efficiency of chitosan is one of its drawbacks as a gene delivery carrier. Low molecular weight chitosan may help to form small-sized polymer-DNA or small interfering RNA (siRNA) complexes. Folate conjugation may improve gene transfection efficiency because of the promoted uptak...

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Dettagli Bibliografici
Autori principali: Fernandes, Julio C, Qiu, Xingping, Winnik, Francoise M, Benderdour, Mohamed, Zhang, Xiaoling, Dai, Kerong, Shi, Qin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2012
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511191/
https://ncbi.nlm.nih.gov/pubmed/23209368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S35567
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