Systems Analysis of Cancer Cell Heterogeneity in Caspase-dependent Apoptosis Subsequent to Mitochondrial Outer Membrane Permeabilization

Deregulation of apoptosis is a hallmark of carcinogenesis. We here combine live cell imaging and systems modeling to investigate caspase-dependent apoptosis execution subsequent to mitochondrial outer membrane permeabilization (MOMP) in several cancer cell lines. We demonstrate that, although most c...

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Detalhes bibliográficos
Main Authors: Schmid, Jasmin, Dussmann, Heiko, Boukes, Gerhardt J., Flanagan, Lorna, Lindner, Andreas U., O'Connor, Carla L., Rehm, Markus, Prehn, Jochen H. M., Huber, Heinrich J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510850/
https://ncbi.nlm.nih.gov/pubmed/23038270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411827
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