Studies on the Substrate and Stereo/Regioselectivity of Adipose Triglyceride Lipase, Hormone-sensitive Lipase, and Diacylglycerol-O-acyltransferases

Adipose triglyceride lipase (ATGL) is rate-limiting for the initial step of triacylglycerol (TAG) hydrolysis, generating diacylglycerol (DAG) and fatty acids. DAG exists in three stereochemical isoforms. Here we show that ATGL exhibits a strong preference for the hydrolysis of long-chain fatty acid...

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Hauptverfasser: Eichmann, Thomas O., Kumari, Manju, Haas, Joel T., Farese, Robert V., Zimmermann, Robert, Lass, Achim, Zechner, Rudolf
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510842/
https://ncbi.nlm.nih.gov/pubmed/23066022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400416
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